otolithic membranes การใช้

• The otolithic membrane can be affected in patients with M閚i鑢e's disease.
• It is generally associated with natural age-related degeneration of the otolithic membrane.
• A gelatinous cover called the otolithic membrane envelops the tips of the stereocilia and kinocilium.
• In vertical linear acceleration, the weighted otolithic membrane lags behind the stereocilia and kinocilium.
• Covering the surface of the otolithic membrane are otoliths, which are crystals of calcium carbonate.
• The otolithic membrane is weighted with small densely packed protein-calcium carbonate granules called statoconica.
• Supporting cells interdigitate between hair cells and secrete the otolithic membrane, a thick, gelatinous layer of glycoprotein.
• The phenomenon is thought to be triggered by a sudden mechanical disturbance of the otolithic membrane that activates motoneurons in the vestibulospinal tract.
• A shift in the otolithic membrane that stimulates the cilia is considered the state of the body until the cilia are once again stimulated.
• The gelatinous layer and the statoconia together are referred to as the otolithic membrane, where the tips of the stereocilia and kinocilium are embedded.
• Both are made of the same sensory tissue containing hair cells, which is covered by a gelatinous layer and the otolithic membrane on top.
• Benign paroxysmal positional vertigo ( BPPV ) is the most common vestibular system disorder and occurs as a result of otoconia detaching from the otolithic membrane in the utricle and collecting in one of the semicircular canals.
• The stereocilia are oriented by the striola, a curved ridge that runs through the middle of the macula; in the saccule they are oriented away from the striola The tips of the stereocilia and kinocilium are embedded in a gelatinous otolithic membrane.
• The mass of the otolithic membrane relative to the surrounding endolymph, as well as the membrane's physical uncoupling from the underlying macula, means that hair bundle displacement will occur transiently in response to linear accelerations, and tonically in response to tilting of the head.
• The goal of the Epley or Modified Epley maneuver is to restore equilibrium of the vestibular system, more specifically to the semicircular canals to treat the symptoms associated with BPPV . There is compelling evidence that free floating otoconia, probably displaced from the otolithic membrane in the utricle are the main cause of this disequilibrium.